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He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. \n\nOn this special live episode of How to Build the Future, he sat down with YC's Garry Tan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve and what the next big scientific breakthroughs might be. \n\nChapters:\n00:00 \u2014 Intro\n00:46 \u2014 Demis Hassabis: From Chess Prodigy to DeepMind\n01:48 \u2014 What\u2019s Missing Before We Get To AGI?\n03:36 \u2014 Why Memory Is Still Unsolved\n06:14 \u2014 How AlphaGo Shaped Gemini\n08:06 \u2014 Why Smaller Models Are Getting So Powerful\n10:46 \u2014 The 1000x Engineer\n12:40 \u2014 Continual Learning and the Future of Agents\n13:32 \u2014 Why AI Still Fails at Basic Reasoning\n15:33 \u2014 Are Agents Overhyped or Just Getting Started?\n18:31 \u2014 Can AI Become Truly Creative?\n20:26 \u2014 Open Models, Gemma, and Local AI\n22:26 \u2014 Why Gemini Was Built Multimodal\n24:08 \u2014 What Happens When Inference Gets Cheap?\n25:24 \u2014 From AlphaFold to the Virtual Cells\n28:24 \u2014 AI as the Ultimate Tool for Science\n30:43 \u2014 Advice for Founders\n33:30 \u2014 The AlphaFold Breakthrough Pattern\n35:20 \u2014 Can AI Make Real Scientific Discoveries?\n37:59 \u2014 What to Build Before AGI Arrives\n\nApply to Y Combinator: https:\/\/www.ycombinator.com\/apply\nWork at a startup: https:\/\/www.ycombinator.com\/jobs","thumbnailUrl":["https:\/\/i.ytimg.com\/vi\/JNyuX1zoOgU\/default.jpg","https:\/\/i.ytimg.com\/vi\/JNyuX1zoOgU\/mqdefault.jpg","https:\/\/i.ytimg.com\/vi\/JNyuX1zoOgU\/hqdefault.jpg","https:\/\/i.ytimg.com\/vi\/JNyuX1zoOgU\/sddefault.jpg","https:\/\/i.ytimg.com\/vi\/JNyuX1zoOgU\/maxresdefault.jpg"],"uploadDate":"2026-04-29T14:00:34+00:00","duration":"PT40M57S","embedUrl":"https:\/\/www.youtube.com\/embed\/JNyuX1zoOgU","publisher":{"@type":"Organization","@id":"https:\/\/www.youtube.com\/channel\/UCcefcZRL2oaA_uBNeo5UOWg#Organization","url":"https:\/\/www.youtube.com\/channel\/UCcefcZRL2oaA_uBNeo5UOWg","name":"Y Combinator","description":"All the world is changing around technology and you may contribute a line of code. 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